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Review
. 2011 Jul;32(7):1192-5.
doi: 10.1016/j.neurobiolaging.2011.01.012. Epub 2011 Apr 23.

One-carbon metabolism and Alzheimer's disease: is it all a methylation matter?

Andrea Fuso  1 , Sigfrido Scarpa
Affiliations
Review

One-carbon metabolism and Alzheimer's disease: is it all a methylation matter?

Andrea Fuso et al. Neurobiol Aging. 2011 Jul.

Abstract

The sporadic form of Alzheimer disease, late onset Alzheimer's disease (LOAD), is a multifactorial disease; a strong link between nutritional and genetic factors with normal aging and dementia is supported by studies on nutrition, metabolism, and neurodegeneration. Specifically, the involvement of homocysteine (HCY) and its dietary determinants (vitamins B6, B12, and folate, besides methionine) in dementia has been a topic of intense investigation. In this Commentary we would like to highlight the role of 1-carbon metabolism in epigenetics and Alzheimer's disease and evidence the co-involvement of this metabolism in amyloid and tau pathways.

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Comment on

  • Epigenetic mechanisms in Alzheimer's disease.
    Mastroeni D, Grover A, Delvaux E, Whiteside C, Coleman PD, Rogers J. Mastroeni D, et al. Neurobiol Aging. 2011 Jul;32(7):1161-80. doi: 10.1016/j.neurobiolaging.2010.08.017. Epub 2011 Apr 11. Neurobiol Aging. 2011. PMID: 21482442 Free PMC article. Review.

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