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. 2011 Jun 1;21(11):3417-9.
doi: 10.1016/j.bmcl.2011.03.104. Epub 2011 Apr 5.

New antiplasmodial indole alkaloids from Hunteria zeylanica

Alfarius E Nugroho  1 , Masatomo Sugai, Yusuke Hirasawa, Takahiro Hosoya, Khalijah Awang, A Hamid A Hadi, Wiwied Ekasari, Aty Widyawaruyanti, Hiroshi Morita
Affiliations

New antiplasmodial indole alkaloids from Hunteria zeylanica

Alfarius E Nugroho et al. Bioorg Med Chem Lett. .

Abstract

Two new indole alkaloids, bisnicalaterine D (1), consisting of an eburnane and a corynanthe type of skeletons, and nicalaterine A (2) were isolated from the bark of Hunteria zeylanica. Their structures were elucidated by various spectroscopic data such as NMR and CD spectra. A series of bisnicalaterines and nicalaterine A showed potent antiplasmodial activity against Plasmodium falciparum 3D7.

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