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Review
. 2011 May;34 Suppl 2(Suppl 2):S161-5.
doi: 10.2337/dc11-s212.

Type 2 diabetes in youth: epidemiology and pathophysiology

Ebe D'Adamo  1 , Sonia Caprio
Affiliations
Review

Type 2 diabetes in youth: epidemiology and pathophysiology

Ebe D'Adamo et al. Diabetes Care. 2011 May.
No abstract available

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Figures

Figure 1
Figure 1
Glucose sensitivity of first-phase (σ1, dynamic secretion component) and second-phase (σ2, static secretion component) insulin secretion among NGT, IFG, IGT, and IFG/IGT obese adolescents. (*P = 0.004 IFG vs. NGT; **P = 0.04 IGT vs. NGT; ***P = 0.0001 IFG/IGT vs. NGT; ♦P = 0.02 IGT vs. NGT).
Figure 2
Figure 2
A: Baseline values of the dynamic β-cell responsivity (Φd) in subjects who maintained NGT (nonprogressors [NP]) and in subjects who developed IGT (progressors [P]) (P = 0.04). B: Changes of the DI values according to changes in glucose tolerance over the course of approximately 30 months. Subjects who developed IGT (progressors) experienced a progressive decline of overall β-cell function, as assessed by the DI. OGTT, oral glucose tolerance test.*P = 0.04.
Figure 3
Figure 3
Liver fat content and impairment of insulin sensitivity and β-cell function in obese children and adolescents. The whole-body insulin sensitivity index (WBISI) decreased (P = 0.007) across low (median 0.7%), moderate (median 4.5%), and high (median 28.8%) liver fat content (%) tertiles. The insulinogenic index (IGI) tended to be higher (P = 0.05) and the DI tended to be lower (P = 0.05) in the high tertile compared with the low tertile.
See this image and copyright information in PMC

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