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. 2011 May;34 Suppl 2(Suppl 2):S304-7.
doi: 10.2337/dc11-s244.

Antihypertensive treatment and blood pressure in diabetic and nondiabetic patients: the lower, the better?

Giuseppe Mancia  1 , Guido Grassi, Alberto Zanchetti
Affiliations

Antihypertensive treatment and blood pressure in diabetic and nondiabetic patients: the lower, the better?

Giuseppe Mancia et al. Diabetes Care. 2011 May.
No abstract available

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Figures

Figure 1
Figure 1
Systolic BP (SBP) values achieved in patients randomized to more active (filled rectangles) or less active (open rectangles) treatment in trials on uncomplicated hypertension, in hypertension of the elderly, and in patients with diabetes or previous cardiovascular disease (CVD). Light gray rectangles indicate trials with significant benefits of more active treatment; deep gray rectangles indicate trials without significant benefits; striped rectangles indicate trials with significant benefits of more active treatment limited to some secondary outcomes. Abbreviations at the bottom indicate trials. Modified from Zanchetti et al. (4).
Figure 2
Figure 2
Unadjusted incidence of cardiovascular events in relation to the proportion of visits with BP control in the INVEST trial. Full bars: primary outcomes of the study (all-cause deaths, nonfatal myocardial infarction, and stroke); open bars: fatal and nonfatal myocardial infarction; shaded bars: fatal and nonfatal stroke. Data are shown as percent values. Modified from Mancia et al. (11).
Figure 3
Figure 3
Unadjusted risk of cardiovascular events, cardiovascular mortality, myocardial infarction, and stroke in relation to on-treatment systolic BP (SBP) deciles. Hazard ratio values are also shown for each variable. Data from ONTARGET are shown. Modified from Sleight et al. (16).
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References

    1. Mancia G, De Backer G, Dominiczak A, et al. 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens 2007;25:1105–1187 - PubMed
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    1. Zanchetti A, Grassi G, Mancia G. When should antihypertensive drug treatment be initiated and to what levels should systolic blood pressure be lowered? A critical reappraisal. J Hypertens 2009;27:923–934 - PubMed
    1. Mancia G, Laurent S, Agabiti-Rosei E, et al. Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. J Hypertens 2009;27:2121–2158 - PubMed

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