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. 2011 Jul;80(2):218-24.
doi: 10.1038/ki.2011.114. Epub 2011 Apr 27.

Higher recipient body mass index is associated with post-transplant delayed kidney graft function

Miklos Z Molnar  1 , Csaba P Kovesdy, Istvan Mucsi, Suphamai Bunnapradist, Elani Streja, Mahesh Krishnan, Kamyar Kalantar-Zadeh
Affiliations

Higher recipient body mass index is associated with post-transplant delayed kidney graft function

Miklos Z Molnar et al. Kidney Int. 2011 Jul.

Abstract

To examine whether a higher body mass index (BMI) in kidney recipients is associated with delayed graft function (DGF), we analyzed data from 11,836 hemodialysis patients in the Scientific Registry of Transplant Recipients who underwent kidney transplantation. The patient cohort included women, blacks, and diabetics; the average age was 49 years; and the mean BMI was 26.8 kg/m(2). After adjusting for relevant covariates, multivariate logistic regression analyses found that one standard deviation increase in pretransplant BMI was associated with a higher risk of DGF (odds ratio (OR) 1.35). Compared with patients with a pretransplant BMI of 22-24.99 kg/m(2), overweight patients (BMI 25-29.99 kg/m(2)), mild obesity patients (BMI 30-34.99 kg/m(2)), and moderate-to-severe obesity patients (BMI 35 kg/m(2) and over) had a significantly higher risk of DGF, with ORs of 1.30, 1.42, and 2.18, respectively. Similar associations were found in all subgroups of patients. Hence, pretransplant overweight or obesity is associated with an incrementally higher risk of DGF.

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Conflict of interest statement

Relevant Potential Conflict of Interest:

Dr. Krishnan is an employee of DaVita. Dr. Kalantar-Zadeh is the medical director of DaVita Harbor-UCLA/MFI in Long Beach, CA. Other authors have not declared any conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of the patient selection (see text)
Figure 2
Figure 2
Multivariate analysis of logistic regression models showing pre-transplant BMI and OR (and 95% CI as error bars) of delayed graft function in four different models (Reference: BMI 22-<25 kg/m2)
Figure 3
Figure 3
Multivariate analysis of fully adjusted (for case-mix, MICS and transplant covariates) logistic regression models showing pre-transplant BMI and OR (and 95% CI as error bars) of delayed graft function for each standard deviation higher BMI in different sub-group of patients
See this image and copyright information in PMC

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