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Case Reports
. 2011 Mar 29;4(1):175-7.
doi: 10.1159/000327363.

Leser-Trélat Sign without Internal Malignancy

Gilles Safa  1 , Laure Darrieux
Affiliations
Case Reports

Leser-Trélat Sign without Internal Malignancy

Gilles Safa et al. Case Rep Oncol. .

Abstract

Leser-Trélat sign is characterized by the abrupt appearance of multiple seborrheic keratoses in association with underlying malignant disease. A case of Leser-Trélat sign in a 66-year-old healthy woman is presented. Evaluation and follow-up for the development of malignancy over a 2-year period failed to reveal any evidence of malignancy. To date, almost all cases of Leser-Trélat sign have been reported in association with an underlying malignancy. It is less known that Leser-Trélat sign can also occur in healthy individuals in the absence of internal malignancy.

Keywords: Leser-Trélat sign; Paraneoplastic syndrome; Seborrheic keratoses.

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Figures

Fig. 1
Fig. 1
Sudden onset of multiple seborrheic keratoses on the back.
See this image and copyright information in PMC

References

    1. Schwartz RA. Sign of Leser-Trélat. J Am Acad Dermatol. 1996;35:88–95. - PubMed
    1. Rampen FHJ, Schwengle LEM. The sign of Leser-Trélat: does it exist? J Am Acad Dermatol. 1989;21:50–55. - PubMed
    1. Grob JJ, Rava MC, Gouvernet J, Fuentes P, Piana L, Gamerre M, Sarles JC, Bonerandi JJ. The relation between seborrheic keratoses and malignant solid tumours. A case-control study. Acta Derm Venereol. 1991;71:166–169. - PubMed
    1. Inamadar AC, Palit A. Eruptive seborrhoeic keratosis in human immunodeficiency virus infection: a coincidence or 'the sign of Leser-Trélat'? Br J Dermatol. 2003;149:435–436. - PubMed
    1. Schwengle LE, Rampen FH. Eruptive seborrheic keratoses associated with erythrodermic pityriasis rubra pilaris. Possible role of retinoid therapy. Acta Derm Venereol. 1988;68:443–445. - PubMed

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