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Meta-Analysis
. 2011 Apr 15;6(4):e18776.
doi: 10.1371/journal.pone.0018776.

Association between alcohol consumption and cancers in the Chinese population--a systematic review and meta-analysis

Ying Li  1 , Huan Yang, Jia Cao
Affiliations
Meta-Analysis

Association between alcohol consumption and cancers in the Chinese population--a systematic review and meta-analysis

Ying Li et al. PLoS One. .

Abstract

Background: Alcohol consumption is increasing worldwide and is associated with numerous cancers. This systematic review examined the role of alcohol in the incidence of cancer in the Chinese population.

Methods: Medline/PubMed, EMBASE, CNKI and VIP were searched to identify relevant studies. Cohort and case-control studies on the effect of alcohol use on cancers in Chinese were included. Study quality was evaluated using the Newcastle-Ottawa Scale. Data were independently abstracted by two reviewers. Odds ratios (OR) or relative risks (RR) were pooled using RevMan 5.0. Heterogeneity was evaluated using the Q test and I-squared statistic. P<.01 was considered statistically significant.

Results: Pooled results from cohort studies indicated that alcohol consumption was not associated with gastric cancer, esophageal cancers (EC) or lung cancer. Meta-analysis of case-control studies showed that alcohol consumption was a significant risk factor for five cancers; the pooled ORs were 1.79 (99% CI, 1.47-2.17) EC, 1.40 (99% CI, 1.19-1.64) gastric cancer, 1.56 (99% CI, 1.16-2.09) hepatocellular carcinoma, 1.21 (99% CI, 1.00-1.46) nasopharyngeal cancer and 1.71 (99% CI, 1.20-2.44) oral cancer. Pooled ORs of the case-control studies showed that alcohol consumption was protective for female breast cancer and gallbladder cancer: OR 0.76 (99% CI, 0.60-0.97) and 0.70 (99% CI, 0.49-1.00) respectively. There was no significant correlation between alcohol consumption and lung cancer, colorectal cancer, pancreatic cancer, cancer of the ampulla of Vater, prostate cancer or extrahepatic cholangiocarcinoma. Combined results of case-control and cohort studies showed that alcohol consumption was associated with 1.78- and 1.40-fold higher risks of EC and gastric cancer but was not significantly associated with lung cancer.

Conclusions: Health programs focused on limiting alcohol intake may be important for cancer control in China. Further studies are needed to examine the interaction between alcohol consumption and other risk factors for cancers in Chinese and other populations.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Results of literature search.
This figure describes the whole process of searching for articles for inclusion in this systematic review and meta-analysis.
Figure 2
Figure 2. Forest plot of relative risk estimates of incident EC, gastric cancer, and lung cancer by alcohol consumption in Chinese.
This figure shows forest plots for the meta-analysis of the association between alcohol consumption and the risk of EC, gastric cancer, and lung cancer. OR and the 99% CI for each cancer was given.
Figure 3
Figure 3. Forest plot of relative risk estimates of incident HCC, colorectal cancer, breast cancer and pancreatic cancer by alcohol consumption in Chinese.
This figure shows forest plots for the meta-analysis of the association between alcohol consumption and the risk of HCC, colorectal cancer, breast cancer and pancreatic cancer. OR and the 99% CI for each cancer was given.
Figure 4
Figure 4. Forest plot of relative risk estimates of incident nasopharyngeal cancer, cancer of the ampulla of Vater, prostate cancer, oral cancer, gallbladder cancer and ECC by alcohol consumption in Chinese.
This figure shows the forest plots for the meta-analysis of the association between alcohol consumption and the risk of nasopharyngeal cancer, cancer of the ampulla of Vater, prostate cancer, oral cancer, gallbladder cancer and ECC. OR and the 99% CI for each cancer was given.
See this image and copyright information in PMC

References

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    1. Chinese nutrition society. Dietary Guidelines for Chinese People. 2007 ed. Lhasa: Tibet Peoples Publishing press; 2008. pp. 90–95.

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