Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1990 Oct;118(10):1123-8.

[Carbamazepine: the bioavailability of 4 oral pharmaceutical products]

[Article in Spanish]
I Saavedra  1 , A Passalacqua, H Chávez, L Biagini, D Galdames
Affiliations
  • PMID: 2152631
Comparative Study

[Carbamazepine: the bioavailability of 4 oral pharmaceutical products]

[Article in Spanish]
I Saavedra et al. Rev Med Chil. 1990 Oct.

Abstract

The bioavailability of carbamazepine from 4 commercially available products was evaluated in 12 healthy volunteers. A crossover design was used and each patients received 400 mg of each product. Plasma levels of the drug were determined periodically for 72 h using a gas-liquid chromatographic method. An open model of one compartment for first-order absorption was assumed to derive pharmacokinetic parameters. Dissolution kinetics was also evaluated in each product. Significant differences in bioavailability were shown for one product. Results correlated with the in vitro dissolution findings.

PubMed Disclaimer

Publication types