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. 2011 Jun 17;76(12):4930-40.
doi: 10.1021/jo2005928. Epub 2011 May 19.

One-pot reductive amination and Suzuki-Miyaura cross-coupling of formyl aryl and heteroaryl MIDA boronates in array format

Jonathan E Grob  1 , Jill Nunez, Michael A Dechantsreiter, Lawrence G Hamann
Affiliations

One-pot reductive amination and Suzuki-Miyaura cross-coupling of formyl aryl and heteroaryl MIDA boronates in array format

Jonathan E Grob et al. J Org Chem. .

Abstract

Formyl-substituted aryl and heteroaryl MIDA boronates were prepared by a DMSO-free method and used in the first reported one-pot reductive amination-Suzuki-Miyaura cross-coupling sequence. This sequence was then carried out in parallel array format, using microwave-assisted in situ release cross-coupling of MIDA boronates to generate a library with diversity along two axes, affording rapid and convenient access to an array of druglike molecules.

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