Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Fall;6(2):87-92.

An in vitro antimicrobial activity of ten Iranian-made toothpastes

Mostafa Sadeghi  1 , Shokrollah Assar
Affiliations

An in vitro antimicrobial activity of ten Iranian-made toothpastes

Mostafa Sadeghi et al. Dent Res J (Isfahan). 2009 Fall.

Abstract

Background: Antimicrobial agents have been used as a chemotherapeutic agent to improve oral health. This in vitro study was carried out to determine the antimicrobial activity of ten Iranian-made toothpastes against commonly found bacteria in the oral cavity.

Methods: The microorganisms used in this study were Streptococcus mutans, Streptococcus sanguis, Actinomyces viscosus and Candida albicans. Sterile discs impregnated with 10 Iranian-made toothpastes; Paveh, Saviz, Latifeh II, Bath, Darugar II, Darugar I, Close up, Tage, Pooneh III and Nasim, which were separately used on agar plates. Crest Cavity Protection toothpaste and Sterile pyrogenfree distilled water were used as positive and negative controls, respectively. The samples were tested in triplicate, at full strength, 1:1 and 1:3 dilutions. Inhibition zones were measured in millimeter after 48 hr. The data were analyzed by the ANOVA and t-test.

Results: All tested toothpastes demonstrated an antimicrobial activity. The antimicrobial activity of Bath on S. mutans, Paveh on S. sanguis, Paveh, Saviz, Latifeh III and Darugar II on C. albicans were similar to the activity of Crest Cavity Protection. The antimicrobial activity of Pooneh III and Nasim on S. mutans, Bath on S. sanguis and A. viscosus, and Bath and Pooneh III on C. albicans were significantly higher and the others were significantly lower than the positive control. While, the activity of Crest Cavity Protection was the same as Pooneh III, it showed a weaker activity compared with Bath.

Conclusion: Apart from Bath and Pooneh III, the other Iranian-made toothpastes tested in this study showed a lower antimicrobial activity compared to Crest Cavity Protection.

Keywords: Anti-infective agents; Iran Toothpaste; Oral hygiene.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Pannuti CM, Mattos JP, Ranoya PN, Jesus AM, Lotufo RF, Romito GA. Clinical effect of a herbal dentifrice on the control of plaque and gingivitis: a double-blind study. Pesqui Odontol Bras. 2003;17(4):314–8. - PubMed
    1. Moran J, Addy M, Newcombe R. The antibacterial effect of toothpastes on the salivary flora. J Clin Periodontol. 1988;15(3):193–9. - PubMed
    1. Jenkins S, Addy M, Newcombe R. The effects of 0.5% chlorhexidine and 0.2% triclosan containing toothpastes on salivary bacterial counts. J Clin Periodontol. 1990;17(2):85–89. - PubMed
    1. Fine DH, Furgang D, Markowitz K, Sreenivasan PK, Klimpel K, De Vizio W. The antimicrobial effect of a triclosan/copolymer dentifrice on oral microorganisms in vivo. J Am Dent Assoc. 2006;137(10):1406–13. - PubMed
    1. White DJ, Kozak KM, Gibb R, Dunavent J, Klukowska M, Sagel PA. A 24-hour dental plaque prevention study with a stannous fluoride dentifrice containing hexametaphosphate. J Contemp Dent Pract. 2006;7(3):1–11. - PubMed

LinkOut - more resources