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. 2011 Apr 15;3(4):49-59.
doi: 10.4251/wjgo.v3.i4.49.

Markers of bile duct tumors

Giulia Malaguarnera  1 , Maria Giordano, Isabella Paladina, Alessandra Rando, Mario Uccello, Francesco Basile, Antonio Biondi, Santo Carnazzo, Innocenza Alessandria, Clorinda Mazzarino
Affiliations

Markers of bile duct tumors

Giulia Malaguarnera et al. World J Gastrointest Oncol. .

Abstract

Biliary tract carcinomas are relatively rare, representing less than 1% of cancers. However, their incidence has increased in Japan and in industrialized countries like the USA. Biliary tract tumors have a poor prognosis and a high mortality rate because they are usually detected late in the course of the disease; therapeutic treatment options are often limited and of minimal utility. Recent studies have shown the importance of serum and molecular markers in the diagnosis and follow up of biliary tract tumors. This review aims to introduce the main features of the most important serum and molecular markers of biliary tree tumors. Some considerable tumor markers are cancer antigen 125, carbohydrate antigen 19-9, carcinoembryonic antigen, chromogranin A, mucin 1, mucin 5, alpha-fetoprotein, claudins and cytokeratins.

Keywords: Bile duct tumors; Carbohydrate antigen 19-9; Cholangiocarcinoma; Chromogranin A; Tumor markers.

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References

    1. Alison MR, Poulsom R, Forbes SJ. Update on hepatic stem cells. Liver. 2001;21:367–373. - PubMed
    1. Ikai I, Arii S, Kojiro M, Ichida T, Makuuchi M, Matsuyama Y, Nakanuma Y, Okita K, Omata M, Takayasu K, et al. Reevaluation of prognostic factors for survival after liver resection in patients with hepatocellular carcinoma in a Japanese nationwide survey. Cancer. 2004;101:796–802. - PubMed
    1. Shaib YH, El-Serag HB, Davila JA, Morgan R, McGlynn KA. Risk factors of intrahepatic cholangiocarcinoma in the United States: a case-control study. Gastroenterology. 2005;128:620–626. - PubMed
    1. de Groen PC, Gores GJ, LaRusso NF, Gunderson LL, Nagorney DM. Biliary tract cancers. N Engl J Med. 1999;341:1368–1378. - PubMed
    1. Fong Y, Malhotra S. Gallbladder cancer: recent advances and current guidelines for surgical therapy. Adv Surg. 2001;35:1–20. - PubMed