A potential link between dorsomedial hypothalamic nucleus NPY and energy balance
- PMID: 21531331
- PMCID: PMC3098526
- DOI: 10.1016/j.cmet.2011.04.006
A potential link between dorsomedial hypothalamic nucleus NPY and energy balance
Abstract
The function of dorsomedial hypothalamic neuropeptide Y (NPY) in energy balance has largely been restricted to lactation-induced hyperphagia. In this issue, Chao et al. (2011) expand this role to include inhibition of both brown fat thermogenesis and conversion of white-to-brown adipocytes in a white fat depot, resulting in reduced energy expenditure.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
-
Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity.Cell Metab. 2011 May 4;13(5):573-83. doi: 10.1016/j.cmet.2011.02.019. Cell Metab. 2011. PMID: 21531339 Free PMC article.
References
-
- Bamshad M, Aoki VT, Adkison MG, Warren WS, Bartness TJ. Central nervous system origins of the sympathetic nervous system outflow to white adipose tissue. Am J Physiol. 1998;275:R291–R299. - PubMed
-
- Barbatelli G, Murano I, Madsen L, Hao Q, Jimenez M, Kristiansen K, Giacobino JP, De MR, Cinti S. The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation. Am J Physiol Endocrinol Metab. 2010;298:E1244–E1253. - PubMed
-
- Bellinger LL, Bernardis LL. The dorsomedial hypothalamic nucleus and its role in ingestive behavior and body weight regulation: lessons learned from lesioning studies. Physiol Behav. 2002;76:431–442. - PubMed
-
- Bernardis LL, Box BM, Stevenson JAF. Growth following hypothalamic lesions in the weanling rat. Endocrinology. 1963;72:684–692. - PubMed
Publication types
Grants and funding
LinkOut - more resources
Full Text Sources
Miscellaneous
