doi: 10.1016/j.bmcl.2011.04.017.
Epub 2011 Apr 8.
Quinazolinedione sulfonamides: a novel class of competitive AMPA receptor antagonists with oral activity
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- PMID: 21531559
- DOI: 10.1016/j.bmcl.2011.04.017
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Quinazolinedione sulfonamides: a novel class of competitive AMPA receptor antagonists with oral activity
Bioorg Med Chem Lett.
.
Abstract
Quinazoline-2,4-diones with a sulfonamide group attached to the N(3) ring atom constitute a novel class of competitive AMPA receptor antagonists. One of the synthesized compounds, 28, shows nanomolar receptor affinity, whereas other examples of the series display oral anticonvulsant activity in animal models.
Copyright © 2011 Elsevier Ltd. All rights reserved.
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