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. 2011 Jun 1;21(11):3358-61.
doi: 10.1016/j.bmcl.2011.04.017. Epub 2011 Apr 8.

Quinazolinedione sulfonamides: a novel class of competitive AMPA receptor antagonists with oral activity

Manuel Koller  1 , Kurt Lingenhoehl, Markus Schmutz, Ivan-Toma Vranesic, Joerg Kallen, Yves P Auberson, David A Carcache, Henri Mattes, Silvio Ofner, David Orain, Stephan Urwyler
Affiliations

Quinazolinedione sulfonamides: a novel class of competitive AMPA receptor antagonists with oral activity

Manuel Koller et al. Bioorg Med Chem Lett. .

Abstract

Quinazoline-2,4-diones with a sulfonamide group attached to the N(3) ring atom constitute a novel class of competitive AMPA receptor antagonists. One of the synthesized compounds, 28, shows nanomolar receptor affinity, whereas other examples of the series display oral anticonvulsant activity in animal models.

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