Review
doi: 10.1016/j.pt.2011.01.002.
Epub 2011 Apr 30.
Harnessing immune responses against Plasmodium for rational vaccine design
Affiliations
- PMID: 21531627
- DOI: 10.1016/j.pt.2011.01.002
Item in Clipboard
Review
Harnessing immune responses against Plasmodium for rational vaccine design
Trends Parasitol.
2011 Jun.
Abstract
In recent years, groundbreaking advances have been made in understanding the biology of and immune mechanisms against the Plasmodium spp. parasite, the causative agent of malaria. Novel features of the Plasmodium life cycle have been unravelled and immune mechanisms, which take place during both infection and immunization, have been dissected. We have undoubtedly enhanced our knowledge, but the question now is how to use this information to manipulate immune responses against Plasmodium and to develop an efficacious malaria vaccine. In this review, we discuss the latest developments in the field and speculate on how immune responses against Plasmodium could be harnessed for rational vaccine design and application.
Similar articles
-
Exoerythrocytic malaria vaccine development: understanding host-parasite immunobiology underscores strategic success.Expert Rev Vaccines. 2002 Oct;1(3):317-40. doi: 10.1586/14760584.1.3.317. Expert Rev Vaccines. 2002. PMID: 12901572 Review.
-
Targeting Plasmodium liver stages: better late than never.Trends Mol Med. 2011 Sep;17(9):527-36. doi: 10.1016/j.molmed.2011.05.008. Epub 2011 Jul 6. Trends Mol Med. 2011. PMID: 21737347 Review.
-
Immune evasion by malaria parasites: a challenge for vaccine development.Curr Opin Immunol. 2009 Jun;21(3):321-30. doi: 10.1016/j.coi.2009.05.015. Epub 2009 Jun 1. Curr Opin Immunol. 2009. PMID: 19493666 Review.
-
A whole parasite vaccine to control the blood stages of Plasmodium: the case for lateral thinking.Trends Parasitol. 2011 Aug;27(8):335-40. doi: 10.1016/j.pt.2011.03.003. Epub 2011 Apr 21. Trends Parasitol. 2011. PMID: 21514227
-
Parasite Recognition and Signaling Mechanisms in Innate Immune Responses to Malaria.Front Immunol. 2018 Dec 19;9:3006. doi: 10.3389/fimmu.2018.03006. eCollection 2018. Front Immunol. 2018. PMID: 30619355 Free PMC article. Review.
Cited by
-
Ethnomedicines and anti-parasitic activities of Pakistani medicinal plants against Plasmodia and Leishmania parasites.Ann Clin Microbiol Antimicrob. 2016 Sep 20;15(1):52. doi: 10.1186/s12941-016-0170-0. Ann Clin Microbiol Antimicrob. 2016. PMID: 27647140 Free PMC article. Review.
-
A histomorphometric study to evaluate the therapeutic effects of biosynthesized silver nanoparticles on the kidneys infected with Plasmodium chabaudi.Open Life Sci. 2024 Oct 23;19(1):20220968. doi: 10.1515/biol-2022-0968. eCollection 2024. Open Life Sci. 2024. PMID: 39450309 Free PMC article.
-
Immunization with apical membrane antigen 1 confers sterile infection-blocking immunity against Plasmodium sporozoite challenge in a rodent model.Infect Immun. 2013 Oct;81(10):3586-99. doi: 10.1128/IAI.00544-13. Epub 2013 Jul 8. Infect Immun. 2013. PMID: 23836827 Free PMC article.
-
Reduced Plasmodium Parasite Burden Associates with CD38+ CD4+ T Cells Displaying Cytolytic Potential and Impaired IFN-γ Production.PLoS Pathog. 2016 Sep 23;12(9):e1005839. doi: 10.1371/journal.ppat.1005839. eCollection 2016 Sep. PLoS Pathog. 2016. PMID: 27662621 Free PMC article. Clinical Trial.
-
OX40 Stimulation Enhances Protective Immune Responses Induced After Vaccination With Attenuated Malaria Parasites.Front Cell Infect Microbiol. 2018 Jul 19;8:247. doi: 10.3389/fcimb.2018.00247. eCollection 2018. Front Cell Infect Microbiol. 2018. PMID: 30073152 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous
