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. 1990 Feb;64(2):639-41.
doi: 10.1128/JVI.64.2.639-641.1990.

Reovirus type 3 binds to antagonist domains of the beta-adrenergic receptor

S T Donta  1 , J D Shanley
Affiliations

Reovirus type 3 binds to antagonist domains of the beta-adrenergic receptor

S T Donta et al. J Virol. 1990 Feb.

Abstract

Reovirus type 3 interfered with the binding of beta-adrenergic antagonist ligands to receptors on Y1 adrenal, C6 glioma, and mouse L cells. This inhibition of beta-adrenergic binding was dose related. Reovirus did not interfere with dopaminergic binding or isoproterenol-induced activation of adenylate cyclase. In addition, reovirus infected Y1 cells, which bind beta-adrenergic antagonist ligands but lack agonist-induced activity. These results suggest that reovirus infection is initiated by binding to antagonist (nonfunctional) domains of the adrenergic receptor complex.

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