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. 1990 Feb;64(2):664-71.
doi: 10.1128/JVI.64.2.664-671.1990.

Very high frequency of reversion to guanidine resistance in clonal pools of guanidine-dependent type 1 poliovirus

J C de la Torre  1 , E Wimmer, J J Holland
Affiliations

Very high frequency of reversion to guanidine resistance in clonal pools of guanidine-dependent type 1 poliovirus

J C de la Torre et al. J Virol. 1990 Feb.

Abstract

We have carefully examined the frequency of guanidine-resistant revertants in six different clonal pools of guanidine-dependent mutants of type 1 poliovirus. The mutation frequency was (6.5 +/- 6.3) x 10(-4) (with all amino acid substitutions occurring at position 227). The minimal corrected base substitution frequency per single nucleotide site in the codon for amino acid 227 was (2.1 +/- 1.9) x 10(-4).

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