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. 1990 Feb;64(2):941-3.
doi: 10.1128/JVI.64.2.941-943.1990.

Cystatin C, a human proteinase inhibitor, blocks replication of herpes simplex virus

L Björck  1 , A Grubb, L Kjellén
Affiliations

Cystatin C, a human proteinase inhibitor, blocks replication of herpes simplex virus

L Björck et al. J Virol. 1990 Feb.

Abstract

Cystatin C is a human cysteine proteinase inhibitor present in extracellular fluids. Cystatin C and a tripeptide derivative (Z-LVG-CHN2) that mimics its proteinase-binding center, were tested for possible antiviral activity against herpes simplex virus type 1 (HSV) and poliovirus type 1. Both recombinant cystatin C and Z-LVG-CHN2 displayed strong inhibitory effects on HSV replication, whereas no significant effect on poliovirus replication was seen. The molar concentration of cystatin C that gave total inhibition of HSV replication was lower than that of either Z-LVG-CHN2 or of acyclovir, the drug currently most used against HSV infections. These results suggest that cysteine proteinase inhibitors might play a physiological role as inhibitors of viral replication and that such proteinase inhibitors, or peptide derivatives that mimic their proteinase-binding centers, might be used as antiviral agents.

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References

    1. Annu Rev Biochem. 1988;57:701-54 - PubMed
    1. Proc Natl Acad Sci U S A. 1988 Nov;85(21):7872-6 - PubMed
    1. Intervirology. 1988;29(6):334-8 - PubMed
    1. Arch Biochem Biophys. 1986 Sep;249(2):489-99 - PubMed
    1. J Biol Chem. 1981 Feb 25;256(4):1923-8 - PubMed

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