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. 2011 May;32(5):543-4.
doi: 10.1038/aps.2011.58. Epub 2011 May 2.

Nanodiamond delivery circumvents tumor resistance to doxorubicin

Xiao-wei Ma  1 , Yu-liang Zhao, Xing-jie Liang
Affiliations

Nanodiamond delivery circumvents tumor resistance to doxorubicin

Xiao-wei Ma et al. Acta Pharmacol Sin. 2011 May.
No abstract available

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Figures

Figure 1
Figure 1
ND delivery of Dox inhibits tumor growth in murine liver tumor models and mammary carcinoma model. (A) Images of livers/tumors from PBS, Dox, ND, or NDX treated LT2-Myc liver tumor bearing mice. (B) Representative images of excised tumors from PBS, Dox, or NDX treated 4T1 mammary tumor bearing mice. (C) Kaplan-Meier survival plot for LT2-Myc mice treated with PBS (n=5), Dox (100 mg) (n=8), or NDX (100 mg of Dox equivalent) (n=7) by tail vein injection every 7 d. *P<0.03; **P<0.06. (D) Kaplan-Meier survival plot for 4T1 mice treated with PBS (n=7), Dox (100 mg) (n=10), NDX (100 mg of Dox equivalent) (n=10), Dox (200 mg) (n=5), or NDX (200 mg of Dox equivalent) (n=5) by tail vein injection every 6 d. *P<0.003. Reprinted with permission from AAAS: Science Translational Medicine, copyright 2011.
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