Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2011 Oct;26(10):1759-62.
doi: 10.1007/s00467-011-1894-x. Epub 2011 May 1.

Should we consider MMF therapy after rituximab for nephrotic syndrome?

Guido Filler  1 , Shih-Han Susan Huang, Ajay P Sharma
Affiliations
Comment

Should we consider MMF therapy after rituximab for nephrotic syndrome?

Guido Filler et al. Pediatr Nephrol. 2011 Oct.

Abstract

The management of steroid-dependent nephrotic syndrome, especially in patients who have failed to respond to cytotoxic drugs, such as cyclophosphamide, remains challenging. Rituximab represents a new (off-label) therapeutic option. In a significant portion of patients, it has a short serum half-life following the recovery of CD20-positive cells. The addition of mycophenolate mofetil (MMF) as a maintenance therapy is also an attractive option, but one which requires testing in a prospective randomized clinical trial with therapeutic drug monitoring and mechanistic ancillary studies.

PubMed Disclaimer

Comment on

References

    1. Pediatr Nephrol. 2010 Jun;25(6):1193 - PubMed
    1. Int Urol Nephrol. 2008;40(3):807-10 - PubMed
    1. Pediatr Nephrol. 2004 Jan;19(1):101-4 - PubMed
    1. Pediatr Nephrol. 2009 Sep;24(9):1753-5 - PubMed
    1. Pediatrics. 2010 Jul;126(1):e243-6 - PubMed

MeSH terms

LinkOut - more resources