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. 2011 Jun 24;74(6):1508-12.
doi: 10.1021/np200058c. Epub 2011 May 2.

Tigliane-type diterpenoid glycosides from Euphorbia fischeriana

Li-Li Pan  1 , Ping-Lei Fang, Xing-Jie Zhang, Wei Ni, Lei Li, Liu-Meng Yang, Chang-Xiang Chen, Yong-Tang Zheng, Chang-Tian Li, Xiao-Jiang Hao, Hai-Yang Liu
Affiliations

Tigliane-type diterpenoid glycosides from Euphorbia fischeriana

Li-Li Pan et al. J Nat Prod. .

Abstract

Investigation of whole plants of Euphorbia fischeriana afforded three new tigliane-diterpenoid glycosides, fischerosides A-C (1-3), together with 11 known diterpenoids. Fischerosides A-C (1-3) are the first tigliane-type diterpenoid glucosides. Their structures were determined by a combination of 1D and 2D NMR, MS, and acid hydrolysis. Inhibitory activity against HIV-1 was assessed for compounds 1-5. The new compound 3 showed an EC₅₀ value of 0.02 μM and a therapeutic index (TI) of 17.50, while prostratin (4) and 12-deoxyphorbol-13,20-diacetate (5) showed significantly greater anti-HIV-1 activity.

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