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. 2011 Jun 3;13(11):2876-9.
doi: 10.1021/ol2008878. Epub 2011 May 2.

Potassium hydroxide/dimethyl sulfoxide promoted intramolecular cyclization for the synthesis of benzimidazol-2-ones

Astrid Beyer  1 , Christine M M Reucher, Carsten Bolm
Affiliations

Potassium hydroxide/dimethyl sulfoxide promoted intramolecular cyclization for the synthesis of benzimidazol-2-ones

Astrid Beyer et al. Org Lett. .

Abstract

A new protocol for intramolecular N-arylations of ureas to form benzimidazol-2-ones has been developed. The cyclization reaction occurs in the presence of KOH and DMSO at close to ambient temperature. Under these conditions the yields are high and a wide range of functional groups are tolerated.

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