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. 2011 Apr;204(4):171-9.
doi: 10.1016/j.cancergen.2011.03.002.

Philadelphia Chromosome Symposium: commemoration of the 50th anniversary of the discovery of the Ph chromosome

H Sharat Chandra  1 , Nora C Heisterkamp, Alice Hungerford, Jennifer J D Morrissette, Peter C Nowell, Janet D Rowley, Joseph R Testa
Affiliations

Philadelphia Chromosome Symposium: commemoration of the 50th anniversary of the discovery of the Ph chromosome

H Sharat Chandra et al. Cancer Genet. 2011 Apr.

Abstract

This report summarizes highlights of the Philadelphia Chromosome Symposium: Past, Present and Future, held September 28, 2010, to commemorate the 50th anniversary of the discovery of the Philadelphia chromosome. The symposium sessions included presentations by investigators who made seminal contributions concerning the discovery and molecular characterization of the Ph chromosome and others who developed a highly successful therapy based on the specific molecular alteration observed in chronic myeloid leukemia. Additional presentations highlighted future opportunities for the design of molecularly targeted therapies for various types of cancer. Also included here are reminiscences connected with the discovery of the Ph chromosome by David Hungerford and Peter Nowell, the discovery that the abnormality arises from a chromosomal translocation, by Janet Rowley, and the cloning of the 9;22 translocation breakpoints by Nora Heisterkamp, John Groffen, and colleagues.

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Figures

Fig. 1
Fig. 1
Speakers, organizers and other invited guests who attended the “Philadelphia Chromosome Symposium”. Front, from left: Janet Rowley, Alice Hungerford (holding photo of David Hungerford), John Goldman, Nora Heisterkamp, Charles Sawyers, and Hope Punnett. Rear, from left: Felix Mitelman, Alfred Knudson, Joseph Testa, Peter Nowell, Nicholas Lydon, William Sellers, and Owen Witte.
Fig. 2
Fig. 2
Group photograph of cytogeneticists who attended the “Philadelphia Chromosome Symposium: Past, Present and Future,” to commemorate the 50th anniversary of the discovery of the Philadelphia chromosome. The Symposium attracted nearly 200 registrants from 18 States and 10 countries, including Mexico, Canada, India, Australia, and five European nations.
Fig. 3
Fig. 3
Peter Nowell (left) and David Hungerford (right) in 1960, soon after reporting their discovery of the Ph chromosome.
Fig. 4
Fig. 4
Photograph of Janet Rowley from the early 1970s, at about the time of her discovery that the Ph chromosome arises from a 9;22 translocation.
See this image and copyright information in PMC

References

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    1. Nowell PC, Hungerford DA. Aetiology of leukæmia. Lancet. 1960;275:113–4.
    1. Nowell PC, Hungerford DA. Chromosome studies on normal and leukemia human leukocytes. J Natl Cancer Inst. 1960;25:85–109. - PubMed
    1. Rowley JD. A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature. 1973;243:290–3. - PubMed
    1. Heisterkamp N, Stephenson JR, Groffen J, et al. Localization of the c-abl oncogene adjacent to a translocation breakpoint in chronic myelocytic leukemia. Nature. 1983;306:239–42. - PubMed

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