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Comparative Study
. 1990 Jan 15;45(1):77-82.
doi: 10.1002/ijc.2910450115.

Effect of the EBNA-2 gene on the surface antigen phenotype of transfected EBV-negative B-lymphoma lines

P Aman  1 , M Rowe, C Kai, J Finke, L Rymo, E Klein, G Klein
Affiliations
Comparative Study

Effect of the EBNA-2 gene on the surface antigen phenotype of transfected EBV-negative B-lymphoma lines

P Aman et al. Int J Cancer. .

Abstract

Two EBV-negative B-lymphoma cell lines with different phenotypes were transfected with the Epstein-Barr virus EBNA-2 gene. The effects on the expression of 8 B-cell surface markers were analyzed by immunofluorescence methods. In one of the EBNA-2 transfected cell lines, the expression of the CR2 receptor CD21 was induced and the expression of CD23 was enhanced. The results suggest that the EBNA-2 gene is involved in the regulation of CD21 and CD23 in EBV-carrying cells.

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