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Editorial
. 2011 Jun;57(6):1056-7.
doi: 10.1161/HYPERTENSIONAHA.111.173427. Epub 2011 May 2.

Estrogen-independent activation of estrogen receptors

Matthias Barton, Matthias R Meyer, Eric R Prossnitz
Editorial

Estrogen-independent activation of estrogen receptors

Matthias Barton et al. Hypertension. 2011 Jun.
No abstract available

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Conflict of interest statement

Conflicts of Interest

None

Figures

Figure 1
Figure 1
Estrogen receptor-dependent protective effects of olmesartan in ischemia-induced brain injury in estrogen (E2)-deficient states such as menopause (natural or following ovariectomy). The angiotensin AT1 receptor antagonist olmesartan (Olm) increases expression and posphorylation of ERα. This results in up-regulation of the ACE2, Bcl-2 and Bcl-xL genes in an E2-independent manner, an effect that is blocked by the ERα antagonist ICI 182,780 (ICI). ICI also acts as an agonist of GPER. +, activation; -, inhibition.
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Comment on

References

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