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Comment
. 2011 May-Jun;5(3):198-200.
doi: 10.4161/chan.5.3.15873. Epub 2011 May 1.

Mechanism of K+/Na+ selectivity in potassium channels from the perspective of the non-selective bacterial channel NaK

Serdar Durdagi  1 , Sergei Y Noskov
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Comment

Mechanism of K+/Na+ selectivity in potassium channels from the perspective of the non-selective bacterial channel NaK

Serdar Durdagi et al. Channels (Austin). 2011 May-Jun.
Free article

Abstract

Studies of the non-selective NaK channel as a model system provided detailed structural and functional insights into different factors that modulate selective ion conductance. The combination of structural and functional studies of WT- and mutant forms of NaK channel show that apparent conservation of the multiple binding sites in the canonical selectivity filter of K-channel is essential component of the observed robust Na (+) discrimination.

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