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Comment
. 2011 May;13(5):523-5.
doi: 10.1038/ncb0511-523.

iPS cells forgive but do not forget

Maria J Barrero, Juan Carlos Izpisua Belmonte
Comment

iPS cells forgive but do not forget

Maria J Barrero et al. Nat Cell Biol. 2011 May.

Abstract

Induced pluripotent stem (iPS) cells offer the possibility to generate patient-specific cell types for use in regenerative medicine. However, a long-lasting question remains: are iPS and embryonic stem cells equivalent? iPS cells retain a transcriptional memory of their origin, which is now shown to endure with passages and to correlate with defects in the re-establishment of DNA methylation. Both selective pressure and genomic environment may account for these defects.

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References

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