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. 1996 Oct;9(4):659-67.
doi: 10.3892/ijo.9.4.659.

Radioimmunolymphoscintigraphy in the preoperative staging of primary breast cancer

A Pecking  1 , F Gougeonbertrand, F Lokiec, J Murray, R Subramanian, A Boudinet, J Floiras, M Haspel, J Klein, S Shaban, R Dejager, M Hanna
Affiliations

Radioimmunolymphoscintigraphy in the preoperative staging of primary breast cancer

A Pecking et al. Int J Oncol. 1996 Oct.

Abstract

Thirty-one primary breast cancer patients were evaluated by radioimmunolymphoscintigraphy (RILS) and ex vivo scintigraphy (EVS) following subcutaneous injection of human monoclonal antibody In-111-LiLo-16.88. Lymph nodes (370) were assessed by EVS, pathology and immunohistochemistry. The positive predictive value (EVS) for antigen positive nodes, metastatic and hyperplastic, was 90% in stages O-IIB, and the sensitivity and specificity for all stages were 60% and 80% respectively. Four EVS positive nodes with follicular hyperplasia contained micrometastases. RILS and EVS correlate well by the Spearman Rank test (R=0.87). These results suggest RILS may be clinically useful and selectively limit the extent of the surgical procedure.

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