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. 1990 Jan 15;265(2):415-9.
doi: 10.1042/bj2650415.

Mitochondria have Fe(III) receptors

J Weaver  1 , H Zhan, S Pollack
Affiliations

Mitochondria have Fe(III) receptors

J Weaver et al. Biochem J. .

Abstract

Recent work has provided new evidence that ATP is the major constituent of the low-Mr iron pool in the reticulocyte. The interaction of the iron complex of ATP with mitochondria was investigated in the present experiments. When ATP-Fe3+ was incubated with mitochondria, Fe3+, free of ATP, bound with high affinity to Fe3+ receptors on the mitochondria. The binding was saturable and reversible. Iron which was complexed to PPi, nitrilotriacetate, citrate, ADP and GTP also showed saturable binding to mitochondria; Fe3+ complexed to AMP bound non-specifically, as did Fe2+/ascorbate complexed to AMP bound non-specifically, as did Fe2+/ascorbate and Fe2+/dithionite.

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