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Review
. 2011 May;52 Suppl 3(0 3):33-9.
doi: 10.1111/j.1528-1167.2011.03034.x.

Molecular cascades that mediate the influence of inflammation on epilepsy

Alon Friedman  1 , Ray Dingledine
Affiliations
Review

Molecular cascades that mediate the influence of inflammation on epilepsy

Alon Friedman et al. Epilepsia. 2011 May.

Abstract

Experimental evidence strongly indicates a significant role for inflammatory and immune mediators in initiation of seizures and epileptogenesis. Here we will summarize data supporting the involvement of IL-1β, TNF-α and toll-like receptor 4 in seizure generation and the process of epileptogenesis. The physiological homeostasis and control over brain immune response depends on the integrity of the blood-brain barrier, transforming growth factor (TGF)-β signaling and leukocyte migration. To what extent targeting the immune system is successful in preventing epileptogenesis, and which signaling pathway should be beleaguered is still under intensive research.

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Conflict of interest statement

Disclosure

The authors have no conflicts of interest to disclose. We confirm that we have read the Journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.

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