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Randomized Controlled Trial
. 2011 Jul;49(7):2772-3.
doi: 10.1128/JCM.00835-11. Epub 2011 May 4.

Lack of association of small-colony-variant Staphylococcus aureus strains with long-term use of azithromycin in patients with cystic fibrosis

Nicole Green, Jane L Burns, Nicole Mayer-Hamblett, Margaret Kloster, Larry C Lands, Michael Anstead, Felix Ratjen, Lisa Saiman
Randomized Controlled Trial

Lack of association of small-colony-variant Staphylococcus aureus strains with long-term use of azithromycin in patients with cystic fibrosis

Nicole Green et al. J Clin Microbiol. 2011 Jul.
No abstract available

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References

    1. Besier S., et al. 2008. The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates. Antimicrob. Agents Chemother. 52:2183–2189 - PMC - PubMed
    1. Prunier A. L., et al. 2003. High rate of macrolide resistance in Staphylococcus aureus strains from patients with cystic fibrosis reveals high proportions of hypermutable strains. J. Infect. Dis. 187:1709–1716 - PubMed
    1. Saiman L., et al. 2010. Effect of azithromycin on pulmonary function in patients with cystic fibrosis uninfected with Pseudomonas aeruginosa. JAMA 303:1707–1715 - PubMed
    1. Von Eiff C., Peters G., Becker K. 2006. The small colony variant (SCV) concept—the role of staphylococcal SCVs in persistent infections. Injury 37(Suppl. 2):S26–S33 - PubMed

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