Review
doi: 10.1038/mi.2011.20.
Epub 2011 May 4.
The tale of TL1A in inflammation
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- PMID: 21544073
- DOI: 10.1038/mi.2011.20
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Review
The tale of TL1A in inflammation
Mucosal Immunol.
2011 Jul.
Free article
Abstract
TL1A (also known as TNFSF15) is a tumor necrosis factor (TNF) family member expressed by monocytes, macrophages, dendritic cells (DCs), synovial fibroblasts, and endothelial cells in response to stimulation by cytokines, immune complexes, and microorganisms. Its cell surface receptor, DR3 (also known as TNFSF25, WSL-1, TRAMP, and LARD), is mainly expressed by T cells.
Comment on
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Sustained TL1A expression modulates effector and regulatory T-cell responses and drives intestinal goblet cell hyperplasia.Mucosal Immunol. 2011 Mar;4(2):186-96. doi: 10.1038/mi.2010.70. Epub 2010 Oct 20. Mucosal Immunol. 2011. PMID: 20962771 Free PMC article.
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The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation.Mucosal Immunol. 2011 Mar;4(2):172-85. doi: 10.1038/mi.2010.67. Epub 2010 Oct 27. Mucosal Immunol. 2011. PMID: 20980995 Free PMC article.
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