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. 1990 Mar;64(3):1348-52.
doi: 10.1128/JVI.64.3.1348-1352.1990.

Soluble recombinant CR2 (CD21) inhibits Epstein-Barr virus infection

G R Nemerow  1 , J J Mullen 3rd, P W Dickson, N R Cooper
Affiliations

Soluble recombinant CR2 (CD21) inhibits Epstein-Barr virus infection

G R Nemerow et al. J Virol. 1990 Mar.

Abstract

Epstein-Barr virus (EBV), an oncogenic herpesvirus of humans, displays selective tropism for B lymphocytes and epithelial cells. EBV tropism is thought to be determined in part by a unique host cell receptor termed CR2 (CD21). Although previous studies have demonstrated that CR2 mediates EBV binding to B cells, its role in initiating EBV infection and B-cell transformation is less certain. In the studies reported here, soluble recombinant CR2 was shown to cause substantial inhibition of EBV infection of B cells in vitro, indicating that CR2 binding initiates EBV infection. Soluble CR2 may represent a therapeutic agent for acute and chronic EBV infections in humans.

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