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Comparative Study
. 1990 Mar;64(3):1353-6.
doi: 10.1128/JVI.64.3.1353-1356.1990.

Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein

N Dyson  1 , R Bernards, S H Friend, L R Gooding, J A Hassell, E O Major, J M Pipas, T Vandyke, E Harlow
Affiliations
Comparative Study

Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein

N Dyson et al. J Virol. 1990 Mar.

Abstract

Stable protein complexes between the large T antigens of mouse, monkey, baboon, or human polyomaviruses and the retinoblastoma protein were detected by an in vitro coimmunoprecipitation assay. All of the large T antigens tested were able to bind to both human and mouse retinoblastoma polypeptides, showing that these interactions have been conserved during evolution.

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References

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