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Comparative Study
. 1990 Mar;10(3):1234-8.
doi: 10.1128/mcb.10.3.1234-1238.1990.

Members of the 70-kilodalton heat shock protein family contain a highly conserved calmodulin-binding domain

M A Stevenson  1 , S K Calderwood
Affiliations
Comparative Study

Members of the 70-kilodalton heat shock protein family contain a highly conserved calmodulin-binding domain

M A Stevenson et al. Mol Cell Biol. 1990 Mar.

Abstract

The 70-kilodalton heat shock protein (hsp70) family members appear to be essential components in a number cellular protein-protein interactions. We report here on the characterization of a new functional region in hsp70, a calmodulin-binding site. We have identified a 21-amino-acid sequence within the hsp70 protein that contains a calmodulin-binding domain. The peptide formed a potential amphipathic alpha helix and bound calmodulin with high affinity. Comparison of amino acid homology of this calmodulin-binding sequence with analogous hsp70 sequences from other species showed a high degree of conservation.

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