doi: 10.1016/0304-3940(90)90651-o.
Activation of the glycine site in the NMDA receptor is necessary for the induction of LTP
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- PMID: 2154725
- DOI: 10.1016/0304-3940(90)90651-o
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Activation of the glycine site in the NMDA receptor is necessary for the induction of LTP
Neurosci Lett.
.
Abstract
The effects of 7-chlorokynurenate (7-C1KY) were examined on N-methyl-D-aspartate (NMDA) receptor-mediated synaptic mechanisms in the CA1 region of rat hippocampal slices. 7-C1KY depressed both the NMDA receptor-mediated component of synaptic transmission recorded in Mg2(+)-free medium and the induction of long-term potentiation (LTP) in Mg2(+)-containing medium. Both of these effects were reversed by D-serine, suggesting that the action of 7-C1KY was at the allosteric glycine site on the NMDA receptor.
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