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Case Reports
. 2011:2011:134295.
doi: 10.1155/2011/134295. Epub 2011 Apr 10.

Resolution of dialyzer membrane-associated thrombocytopenia with use of cellulose triacetate membrane: a case report

Feyisayo Olafiranye  1 , Win Kyaw, Oladipupo Olafiranye
Affiliations
Case Reports

Resolution of dialyzer membrane-associated thrombocytopenia with use of cellulose triacetate membrane: a case report

Feyisayo Olafiranye et al. Case Rep Med. 2011.

Abstract

Blood and dialyzer membrane interaction can cause significant thrombocytopenia through the activation of complement system. The extent of this interaction determines the biocompatibility of the membrane. Although the newer synthetic membranes have been shown to have better biocompatibility profile than the cellulose-based membranes, little is known about the difference in biocompatibility between synthetic membrane and modified cellulose membrane. Herein, we report a case of a patient on hemodialysis who developed dialyzer-membrane-related thrombocytopenia with use of synthetic membrane (F200NR polysulfone). The diagnosis of dialyzer membrane-associated thrombocytopenia was suspected by the trend of platelet count before and after dialysis, and the absence of other possible causes of thrombocytopenia. We observed significant improvement in platelet count when the membrane was changed to modified cellulose membrane (cellulose triacetate). In patients at high risk for thrombocytopenia, the modified cellulose membrane could be a better alternative to the standard synthetic membranes during hemodialysis.

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Figures

Figure 1
Figure 1
The trend of platelet counts before and after hemodialysis with polysulfone (PS) and cellulose triacetate (CTA) dialyzer membrane.
See this image and copyright information in PMC

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