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. 2011 Jun 14;47(22):6371-3.
doi: 10.1039/c1cc10377f. Epub 2011 May 6.

Structure inducing ionic liquids-enhancement of alpha helicity in the Abeta(1-40) peptide from Alzheimer's disease

Natalie Debeljuh  1 , Colin J Barrow, Luke Henderson, Nolene Byrne
Affiliations

Structure inducing ionic liquids-enhancement of alpha helicity in the Abeta(1-40) peptide from Alzheimer's disease

Natalie Debeljuh et al. Chem Commun (Camb). .

Abstract

We have studied the impact of ionic liquid solvents on the structure of the Abeta(1-40) peptide from Alzheimer's disease and found that ionic liquid solvents were able to induce a conformational change in the structure of the Abeta(1-40) peptide. This conformational change impacts the self-assembly of the peptide into amyloid fibrils.

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