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. 2011 Dec;104(7):792-7.
doi: 10.1002/jso.21959. Epub 2011 May 5.

Peritoneal carcinomatosis of colon cancer origin: highest incidence in women and in patients with right-sided tumors

Ole Helmer Sjo  1 , Marianne Berg, Marianne Arstad Merok, Matthias Kolberg, Aud Svindland, Ragnhild A Lothe, Arild Nesbakken
Affiliations

Peritoneal carcinomatosis of colon cancer origin: highest incidence in women and in patients with right-sided tumors

Ole Helmer Sjo et al. J Surg Oncol. 2011 Dec.

Abstract

Background and objectives: The aim of the study was to evaluate the incidence of peritoneal carcinomatosis (PC) in a prospectively recorded series of colon cancer patients from a defined cohort and to compare clinicopathological characteristics, survival, and TP53 mutation status in primary tumors from patients with and without PC.

Methods: Clinical data from all colon cancer patients admitted in 1993-2006 were registered prospectively (n = 1,124). In a subset of PC patients, DNA was retrieved from tumor tissue and TP53 mutations analyzed and compared to the mutation status in a historical series.

Results: In the prospective series 10% of female and 7% of male patients had PC (P = 0.05). The PC patients were younger than those without PC (median 4 years, P = 0.002). The incidence of PC was 10.3% and 6.2% (P = 0.03) in patients with primary tumors in the right and left colon, respectively. TP53 was mutated in 57% of the PC patients as compared to 41% in the series of patients without PC (P = 0.05).

Conclusions: The incidence of PC was higher in right-sided colon cancer and among women. PC patients were younger than non-PC patients, and PC was independently associated with TP53 mutation in the primary tumor.

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