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Comment
. 2011 May 17;108(20):8071-2.
doi: 10.1073/pnas.1104843108. Epub 2011 May 6.

In vitro evolution goes deep

Alan M Moses  1 , Alan R Davidson
Affiliations
Comment

In vitro evolution goes deep

Alan M Moses et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Mutated region of yeast Hsp90. The nine residues investigated by Hietpas et al. (4) are shown. The positions that tolerated few substitutions are shown in red, and the others are shown in blue. This figure was generated from Protein Data Bank [PDB ID code 2CG9 (residues A445–A677)] using Pymol (http://www.pymol.org/).
See this image and copyright information in PMC

Comment on

  • Experimental illumination of a fitness landscape.
    Hietpas RT, Jensen JD, Bolon DN. Hietpas RT, et al. Proc Natl Acad Sci U S A. 2011 May 10;108(19):7896-901. doi: 10.1073/pnas.1016024108. Epub 2011 Apr 4. Proc Natl Acad Sci U S A. 2011. PMID: 21464309 Free PMC article.

References

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    1. Hietpas RT, Jensen JD, Bolon DNA. Experimental illumination of a fitness landscape. Proc Natl Acad Sci USA. 2011;108:7896–7901. - PMC - PubMed
    1. Ohta T. Slightly deleterious mutant substitutions in evolution. Nature. 1973;246:96–98. - PubMed

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