doi: 10.1016/0922-4106(90)90251-r.
Different pathways of endothelin/sarafotoxin-stimulated phosphoinositide hydrolysis in myocytes
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- PMID: 2155126
- DOI: 10.1016/0922-4106(90)90251-r
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Different pathways of endothelin/sarafotoxin-stimulated phosphoinositide hydrolysis in myocytes
Eur J Pharmacol.
.
Abstract
Aging of rat heart myocytes in culture is accompanied by approximately 50% reduction in endothelin (ET)/sarafotoxin (SRTX) receptor-binding capacity as well as in the induction of phosphoinositide (PI) hydrolysis. Treatment of aged cultures under conditions yielding myocytes with a lipid composition similar to that in young cultures restored all the ET/SRTX receptors; at the same time it re-established only the endothelin-induced but not the sarafotoxin-induced PI-hydrolysis response. Thus more than one mechanism may stimulate PI metabolism.
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