Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Jan 23;188(1):85-8.
doi: 10.1016/0922-4106(90)90251-r.

Different pathways of endothelin/sarafotoxin-stimulated phosphoinositide hydrolysis in myocytes

R Galron  1 , Y Kloog, A Bdolah, M Sokolovsky
Affiliations

Different pathways of endothelin/sarafotoxin-stimulated phosphoinositide hydrolysis in myocytes

R Galron et al. Eur J Pharmacol. .

Abstract

Aging of rat heart myocytes in culture is accompanied by approximately 50% reduction in endothelin (ET)/sarafotoxin (SRTX) receptor-binding capacity as well as in the induction of phosphoinositide (PI) hydrolysis. Treatment of aged cultures under conditions yielding myocytes with a lipid composition similar to that in young cultures restored all the ET/SRTX receptors; at the same time it re-established only the endothelin-induced but not the sarafotoxin-induced PI-hydrolysis response. Thus more than one mechanism may stimulate PI metabolism.

PubMed Disclaimer

LinkOut - more resources