Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Feb 1;6(1):e1-e6.
doi: 10.1016/j.eclnm.2010.12.003.

Bioimpedance spectroscopy for the estimation of fat-free mass in end-stage renal disease

Sara M Vine  1 , Patricia L Painter, Michael A Kuskowski, Carrie P Earthman
Affiliations

Bioimpedance spectroscopy for the estimation of fat-free mass in end-stage renal disease

Sara M Vine et al. E Spen Eur E J Clin Nutr Metab. .

Abstract

BACKGROUND #ENTITYSTARTX00026; AIMS: Bioimpedance spectroscopy may provide reliable estimates of fat-free mass in end-stage renal disease patients. We aimed to evaluate the ability of bioimpedance spectroscopy to estimate fat-free mass in end-stage renal disease patients using dual-energy X-ray absorptiometry as a reference. METHODS: Fat-free mass measured by bioimpedance spectroscopy was compared to fat-free mass measured by dual-energy X-ray absorptiometry in 16 end-stage renal disease patients on hemodialysis, 12 undialysed end-stage renal disease patients and 23 control subjects. RESULTS: Methods were highly correlated for fat-free mass in all subject groups (r = 0.87, P < 0.001). Mean bioimpedance spectroscopy measures of fat-free mass were not different from the dual-energy X-ray absorptiometry measures in any subject group. Individual comparisons revealed wide limits of agreement between methods in hemodialysis (11.6 to -9.72 kg) and undialysed patients (10.95 to -14.73 kg). CONCLUSIONS: Although bioimpedance spectroscopy estimates of fat-free mass in the end-stage renal disease patient groups were not different from dual-energy X-ray absorptiometry and the methods were highly correlated, there was great individual variability. From these data it is clear that future studies are warranted before bioimpedance spectroscopy can be recommended as a valid clinical tool for assessing fat-free mass in end-stage renal disease patients.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Correlation Between Dual-energy X-ray Absorptiometry and BIS for FFM by Subject Group
Correlation between fat-free mass (FFM) measured by bioimpedance spectroscopy (BIS) and dual-energy X-ray absorptiometry (DXA). The dependent variable was FFM measured by using BIS. In hemodialysis patients (◆), the correlation coefficient (r) was r = 0.924, P < 0.001; in undialysed patients (▲), the correlation coefficient was r = 0.871, P < 0.001and in control subjects (●), the correlation coefficient was r = 0.950, P < 0.001.
Figure 2
Figure 2. (a–c) Bland-Altman Plots of Fat-Free Mass Measures by the ImpediMed Device and Dual-energy X-ray Absorptiometry (Reference) Method
Agreement between bioimpedance spectroscopy (BIS) and dual-energy X-ray absorptiometry (DXA) for measurement of fat-free mass (FFM) in hemodialysis (HD) patients (a), undialysed (UD) patients (b) and control subjects (c) by the Bland & Altman method. Figures show the mean difference (solid line) and 95% limits of agreement between methods (dashed line).
See this image and copyright information in PMC

References

    1. Goldstein-Fuchs J, McQuiston B. Renal Failure - Chapter 33. In: Matarese L, Gottschlich M, editors. Contemporary Nutrition Support Practice. Saunders; St. Louis Missouri: 2006. pp. 460–483.
    1. National Kidney Foundation Kidney Disease Quality Outcome Initiative (K/DOQI). Clinical practice guidelines for nutrition in chronic renal failure. American Journal of Kidney Disease, Am J Kidney Dis. 2000;35:S1–140.
    1. Kopple JD. Effect of nutrition on morbidity and mortality in maintenance dialysis patients. Am J Kidney Dis. 1994;24:1002–1009. - PubMed
    1. Going S. Body Composition Measurement Methods. In: Heymsfield S, Lohman T, Wang Z, Going S, editors. Human Body Composition. Human Kinetics; Champaign, IL: 2005. p. 15.
    1. Chertow GM, Lowrie EG, Wilmore DW, Gonzalez J, Lew NL, Ling J, Leboff MS, Gottlieb MN, Huang W, Zebrowski B. Nutritional assessment with bioelectrical impedance analysis in maintenance hemodialysis patients. J Am Soc Nephrol. 1995;6:75–81. - PubMed

LinkOut - more resources