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. 1987 Jan 1:1:333-340.

IMMUNOSUPPRESSION WITH FR 900506 FOR CANINE KIDNEY AND LIVER TRANSPLANTATION

S Todo  1 , L Makowka, T Starzl
Affiliations

IMMUNOSUPPRESSION WITH FR 900506 FOR CANINE KIDNEY AND LIVER TRANSPLANTATION

S Todo et al. Surg Res Commun. .

Abstract

The immunosuppressive effects of FR 900506 were investigated for one month after canine kidney and liver transplantation. Eight untreated kidney recipients lived for 8 to 19 days, mean 12.1. In contrast, the one month survival of dogs given FR 900506 in daily oral doses of 0.5, 1.0, and 1.5 mg/kg was 2/6, 3/6, and 4/6 respectively. The one month survival of liver recipients was 4/5 compared to one month survival of 1/8 in historical untreated controls. There was no evidence from biochemical tests of hepatotoxicity or nephrotoxicity.

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Figures

FIGURE 1
FIGURE 1
One month survival of Group I (untreated control), Group II (0.5mg/kg/day), Group III (1.0mg/kg/day) and Group IV (1.5mg/kg/day) after kidney transplantation.
FIGURE 2
FIGURE 2
Changes in serum creatinine of Group I (untreated control), Group II (0.5mg/kg/day), Group III (1. 0mg/kg/day) and Group IV (1.5mg/kg/day) after kidney transplantation.
FIGURE 3
FIGURE 3
Changes in SGOT, total bilirubin, BUN and creatinine of animals after liver transplantaion.
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References

    1. OCHIAI T, NAKAJIMA K, NAGATA M, SUZUKI T, ASANO T, UEMATSU T, GOTO T, HORI S, KENMOCHI T, NAGAGOORI T, ISONO K. Effect of a new immunosuppressive agent, FK506, on heterotopic cardiac allotransplantation in the rat. Transplant Proc. 1987;19:1284–1286. - PubMed
    1. ZEEVI A, DUQUESNOY R, EIRAS G, TODO S, MAKOWKA L, STARZL T. In vitro immunosuppressive effects of FR 900506 on human T lymphocyte alloactivation. Surgical Research Communication. 1987 July; In Press. - PMC - PubMed
    1. LEE P, MURASE N, TODO S, MAKOWKA L, STARZL TE. The immunosuppressive effects of FR 900506 in rats receiving heterotopic cardiac allografts. Surgical Research Communication. 1987 July; In Press. - PMC - PubMed
    1. Starzl TE. Experience in renal transplantation. WB Saunders Company; Philadelphia: 1964.
    1. TODO S, KAM I, LYNCH S, STARZL TE. Animal research in liver transplantation with special reference to the dog. Seminar in Liver Disease. 1985;5:309–317. - PMC - PubMed

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