Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987:1:315-323.

IN VITRO IMMUNOSUPPRESSIVE EFFECTS OF FR 900506 ON HUMAN T LYMPHOCYTE ALLOACTIVATION

A Zeevi  1 , R Duquesnoy, G Eiras, S Todo, L Makowka, T Starzl
Affiliations

IN VITRO IMMUNOSUPPRESSIVE EFFECTS OF FR 900506 ON HUMAN T LYMPHOCYTE ALLOACTIVATION

A Zeevi et al. Surg Res Commun. 1987.

Abstract

FR 900506 (FR) is a new immunosuppressive drug which prolongs allograft survival. Our studies have compared the in vitro inhibitory effects of FR and Cyclosporine (CsA) on human lymphocyte proliferation. Considerably lower doses of FR were required to induce inhibition of lymphocyte proliferation induced by concanavalin A (ConA) stimulation or in primary mixed lymphocyte reactions (MLR) Similar differences between FR and CsA were observed with the secondary stimulation of alloactivated T cells generated in MLR or propagated from liver transplant biopsies These observations provide further evidence that FR is about 500 fold more potent than CsA and may be a useful immunosuppressive agent in organ transplantation.

PubMed Disclaimer

Figures

FIGURE 1
FIGURE 1
Inhibition of ConA induced proliferation of lymphocytes by FR and CsA.
FIGURE 2
FIGURE 2
Dose effects of FR and CsA on MLR induced lymphocyte proliferation.
FIGURE 3
FIGURE 3
Immunosuppressive effect of FR and CsA on the PLT reactivity of alloreactive T cell clone DB29.
FIGURE 4
FIGURE 4
Inhibition of donor specific PLT response of alloreactive T cells propagated from a liver transplant biopsy.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. OCHIAI T, NAKAJIMA K, NAGATA M, SUZUKI T, ASANO T, UEMATSU T, GOTO T, HORI S, HENMOCHI T, NAKAGOORI T, ISONO K. Effect of a new immunosuppresive agent, FK 506, on heterotopic cardiac allotransplantation in the rat. Transplant Proc. 1987;19:1284–1286. - PubMed
    1. LEE P, MURASE N, TODO S, MAKOWKA L, STARZL T. The immunosuppressive effects of FR 900506 in rats receiving heterotopic cardiac allografts. Surgical Research Communication. 1987 July; In Press. - PMC - PubMed
    1. TODO S, MAKOWKA L, STARZL T. Immunosuppression with FR 900506 for canine kidney and liver transplantation. Surgical Research Communication. 1987 July; In Press. - PMC - PubMed
    1. ZEEVI A, DUQUESNOY R. Specificity of alloactivated human T lymphocyte clones in secondary proliferation, cell-mediated lympholysis and Interleukin 2 release. J Immunogenet. 1985;12:17–31. - PubMed
    1. FUNG J, ZEEVI A, STARZL T, DEMETRIS J, IWATSUKI S, DUQUESNOY R. Functional characterization of infiltrating T lymphocytes in human allografts. Human Immunol. 1986;16:182–199. - PMC - PubMed

LinkOut - more resources