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Case Reports
. 2011 Jan;28(1):36-8.
doi: 10.4103/0970-9371.76949.

Hemophagocytic syndrome secondary to cytomegalovirus infection in an infant

Anshu Gupta  1 , Rajiv Sen, Charu Batra, Dipankar Banerjee, Anjali Gupta, Medha Jain
Affiliations
Case Reports

Hemophagocytic syndrome secondary to cytomegalovirus infection in an infant

Anshu Gupta et al. J Cytol. 2011 Jan.

Abstract

Virus associated hemophagocytic syndrome is a non-neoplastic, generalized histiocytic proliferation with prominent hemophagocytosis associated with a systemic viral infection. We report a case of cytomegalovirus (CMV) associated hemophagocytic syndrome in a 2 month old male child presenting with rashes, fever, hepatosplenomegaly, cervical lymphadenopathy and pancytopenia. Fine needle aspiration cytology and biopsy from cervical lymph nodes revealed prominent hemophagocytosis. Serology for CMV IgM was positive in both the mother and the child, suggesting recent infection. Possibly there was intrauterine transmission of the infection.

Keywords: Cytomegalovirus; fine needle aspiration cytology; hemophagocytic syndrome.

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Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
Photomicrograph of hypocellular bone marrow smear showing few macrophages and occasional normoblasts (H and E, ×400)
Figure 2
Figure 2
Photomicrograph of FNAC of lymph node, revealing mixed inflammatory infiltrate and histiocytes (H and E ×100); Inset shows a macrophage with phagocytosis of a lymphocyte (H and E, ×1000)
Figure 3
Figure 3
Photomicrograph of lymph node biopsy showing infiltration by heavy inflammatory infiltrate (H and E, ×400)
See this image and copyright information in PMC

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