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Case Reports
. 2011 Apr 15;5(1):232-8.
doi: 10.1159/000327986.

Composite adenocarcinoma and carcinoid gastric tumor in chronic atrophic gastritis and pernicious anemia

Adam C Adler  1 , Cesar Cestero, Eugene H Lewis 3rd, Ingram M Roberts, Eddy A Castillo
Affiliations
Case Reports

Composite adenocarcinoma and carcinoid gastric tumor in chronic atrophic gastritis and pernicious anemia

Adam C Adler et al. Case Rep Gastroenterol. .

Abstract

A 42-year-old Hispanic female was referred for investigation of unexplained weight loss. Initial upper endoscopy showed atrophic gastritis. Repeat endoscopy one year later revealed the presence of mixed composite tumor consisting of gastric adenocarcinoma and carcinoid tumors. Treatment was accomplished by surgical excision. Such cases are extremely rare and few such reports are available in the literature. We discuss the pathologies and means by which these tumors are classified and treated.

Keywords: Adenocarcinoma; Carcinoid; Collision tumor; Neuroendocrine; Stomach.

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Figures

Fig. 1
Fig. 1
Upper endoscopy showing a polypoid mass in the body of the stomach.
Fig. 2
Fig. 2
Endoscopic ultrasound demonstrating the polypoid lesion with extension through the submucosal layer.
Fig. 3
Fig. 3
Repeat endoscopy with resection of the polyp in the body of the stomach.
Fig. 4
Fig. 4
Hematoxylin and eosin staining of the polyp demonstrating glandular tissue (adenocarcinoma) (black arrow) and foci of endocrine cells (carcinoid) (red arrow).
Fig. 5
Fig. 5
Immunoperoxidase stain with positivity for synaptophysin (red arrow) in carcinoid and negativity in adenocarcinoma (black arrow).
See this image and copyright information in PMC

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