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. 2011 May 9;30(1):52.
doi: 10.1186/1756-9966-30-52.

IsoBED: a tool for automatic calculation of biologically equivalent fractionation schedules in radiotherapy using IMRT with a simultaneous integrated boost (SIB) technique

Vicente Bruzzaniti  1 , Armando Abate, Massimo Pedrini, Marcello Benassi, Lidia Strigari
Affiliations

IsoBED: a tool for automatic calculation of biologically equivalent fractionation schedules in radiotherapy using IMRT with a simultaneous integrated boost (SIB) technique

Vicente Bruzzaniti et al. J Exp Clin Cancer Res. .

Abstract

Background: An advantage of the Intensity Modulated Radiotherapy (IMRT) technique is the feasibility to deliver different therapeutic dose levels to PTVs in a single treatment session using the Simultaneous Integrated Boost (SIB) technique. The paper aims to describe an automated tool to calculate the dose to be delivered with the SIB-IMRT technique in different anatomical regions that have the same Biological Equivalent Dose (BED), i.e. IsoBED, compared to the standard fractionation.

Methods: Based on the Linear Quadratic Model (LQM), we developed software that allows treatment schedules, biologically equivalent to standard fractionations, to be calculated. The main radiobiological parameters from literature are included in a database inside the software, which can be updated according to the clinical experience of each Institute. In particular, the BED to each target volume will be computed based on the alpha/beta ratio, total dose and the dose per fraction (generally 2 Gy for a standard fractionation). Then, after selecting the reference target, i.e. the PTV that controls the fractionation, a new total dose and dose per fraction providing the same isoBED will be calculated for each target volume.

Results: The IsoBED Software developed allows: 1) the calculation of new IsoBED treatment schedules derived from standard prescriptions and based on LQM, 2) the conversion of the dose-volume histograms (DVHs) for each Target and OAR to a nominal standard dose at 2Gy per fraction in order to be shown together with the DV-constraints from literature, based on the LQM and radiobiological parameters, and 3) the calculation of Tumor Control Probability (TCP) and Normal Tissue Complication Probability (NTCP) curve versus the prescribed dose to the reference target.

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Figures

Figure 1
Figure 1
OAR DV-constraints provided by IsoBED for prostate case.
Figure 2
Figure 2
OAR DV-constraints provided by IsoBED for Head & Neck case.
Figure 3
Figure 3
OAR DV-constraints provided by IsoBED for Lung case.
Figure 4
Figure 4
Example of IsoBED calculation for the case of prostate and lymph nodes treatment.
Figure 5
Figure 5
DVHs imported from TPSs for Sequential and SIB Technique in a) prostate, b) Head & Neck and c) Lung cases. Numered circles represents the OAR costraints.
Figure 6
Figure 6
NTD2-VH for Sequential and SIB Technique in a) prostate, b) Head & Neck and c) Lung cases. Numered circles represents the OAR costraints.
Figure 7
Figure 7
Radiobiological curves (TCP, NTCP and P+) for Sequential and SIB Technique in a) prostate, b) Head & Neck and c) Lung cases.
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References

    1. Ang KK, Peters LJ. Concomitant boost radiotherapy in the treatment of head and neck cancer. Semin Radiat Oncol. 1992;2:31–33. doi: 10.1016/S1053-4296(05)80049-9. - DOI
    1. Ang KK, Peters LJ, Weber RS. Concomitant boost radiotherapy schedules in the treatment of carcinoma of the oropharynx and nasopharynx. Int J Radiat Oncol Biol Phys. 1990;19:1339–1345. doi: 10.1016/0360-3016(90)90341-G. - DOI - PubMed
    1. Mohan R, Wu Q, Manning M, Schmidt-Ullrich R. Radiobiological considerations in the design of fractionation strategies for intensity-modulated radiation therapy of head and neck cancers. Int J Radiat Oncol Biol Phys. 2000;46(3):619–630. doi: 10.1016/S0360-3016(99)00438-1. - DOI - PubMed
    1. Dogan N, King S, Emami B, Mohideen N, Mirkovic N, Leybovich LB, Sethi A. Assessment of different IMRT boost delivery methods on target coverage and normal-tissue sparing. Int J Radiat Oncol Biol Phys. 2003;57:1480–1491. doi: 10.1016/S0360-3016(03)01569-4. - DOI - PubMed
    1. Fogliata A, Bolsi A, Cozzi L, Bernier J. Comparative dosimetric evaluation of the simultaneous integrated boost with photon intensity modulation in head and neck cancer patients. Radiother Oncol. 2003;69:267–275. doi: 10.1016/j.radonc.2003.10.003. - DOI - PubMed

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