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. 2011 May 9:6:30.
doi: 10.1186/1750-1326-6-30.

Similarities and differences in structure, expression, and functions of VLDLR and ApoER2

Sunil S Reddy  1 , Teal E Connor, Edwin J Weeber, William Rebeck
Affiliations

Similarities and differences in structure, expression, and functions of VLDLR and ApoER2

Sunil S Reddy et al. Mol Neurodegener. .

Abstract

Very Low Density Lipoprotein Receptor (VLDLR) and Apolipoprotein E Receptor 2 (ApoER2) are important receptors in the brain for mediating the signaling effects of the extracellular matrix protein Reelin, affecting neuronal function in development and in the adult brain. VLDLR and ApoER2 are members of the low density lipoprotein family, which also mediates the effects of numerous other extracellular ligands, including apolipoprotein E. Although VLDLR and ApoER2 are highly homologous, they differ in a number of ways, including structural differences, expression patterns, alternative splicing, and binding of extracellular and intracellular proteins. This review aims to summarize important aspects of VLDLR and ApoER2 that may account for interesting recent findings that highlight the unique functions of each receptor.

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Figures

Figure 1
Figure 1
VLDLR and ApoER2 receptors. Specific domains are defined by vertical lines, alternative splice forms are shown with protruding "v"s, exon numbers are noted, and amino acid %-sequence identities of individual domains are indicated.
Figure 2
Figure 2
VLDLR and ApoER2 interacting proteins. Some of the extracellular and intracellular proteins that interact with VLDLR and ApoER2 are indicated.
See this image and copyright information in PMC

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