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Comparative Study
. 1978 Dec;22(3):644-8.
doi: 10.1128/iai.22.3.644-648.1978.

Comparative studies of five heat-labile toxic products of Escherichia coli

J Konowalchuk, N Dickie, S Stavric, J I Speirs
Comparative Study

Comparative studies of five heat-labile toxic products of Escherichia coli

J Konowalchuk et al. Infect Immun. 1978 Dec.

Abstract

Five heat-labile, partially purified toxic products of Escherichia coli were distinguished by isoelectric focusing, molecular weight, and neutralization with homologous and heterologous antisera. Only two affected the morphology of Y-1 cells, induced fluid accumulation in rabbit ileal loops, and stimulated production of cyclic AMP in Vero cells; these two did not cross-neutralize and only one showed cross-neutralization with cholera antitoxin. The remaining three products were cytotoxic for Vero cells.

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